Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Antimicrobial Activities of Sesquiterpene Lactones Isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale

지칭개, 구절초 및 산국에서 분리한 Sesquiterpene lactones의 항균활성

  • Jang, Dae-Sik (Dept. of Agricultural Chemistry, Gyeongsang National University) ;
  • Park, Ki-Hun (Dept. of Agricultural Chemistry, Gyeongsang National University) ;
  • Lee, Jong-Rok (Dept. of Agricultural Chemistry, Gyeongsang National University) ;
  • Ha, Tae-Joung (Dept. of Agricultural Chemistry, Gyeongsang National University) ;
  • Park, Yun-Bae (Dept. of Biochemistry, Gyeongsang National University) ;
  • Nam, Sang-Hae (Dept. of Food Processing, Chinju National University) ;
  • Yang, Min-Suk (Dept. of Agricultural Chemistry, Gyeongsang National University)
  • Published : 1999.05.31
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Abstract

In the bioactivity test of nine sesquiterpene lactons isolated from Hemisteptia lyrata, Chrysanthemum zawadskii and Chrysanthemum boreale, we investigated their antimicrobial activities against ten bacteria and six phytopathogenic fungi. Hemistepsin A and hemistepsin B isolated from H. lyrata and tulipinolide isolated from C. boreale exhibited strong antibacterial activity. In the antifungal test, hemistepsin B, angeloylcumambrin B, tigloylcumambrin B and costunolide showed broad activity. Both antibacterial and antifungal experiments exhibited quite clear specificity against microbial strains.

지칭개, 구절초 및 산국에서 분리한 9종류의 sesquiterpene lactones에 대한 생리활성 실험의 일환으로, 10종의 세균에 대한 항세균활성과 6종의 식물병원균에 대한 항진균활성을 조사하였다. 항세균 활성실험에서는 지칭개에서 분리한 hemistepsin A와 B 그리고 산국에서 분리한 tulipinolide가 시험균주 전반에 대하여 강한 활성을 보였으며, 항진균 활성실험에서는 hemistepsin B, angeloylcumambrin B, tigloylcumambrin B, 그리고 costunolide가 광범위한 활성을 보였다. 또한, 항세균 활성실험과 항진균 활성실험 모두 비교적 뚜렷한 균주특이성을 나타내었다.

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