Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Evaluation of Anticoagulant and Fibrinolytic Activities from Crude Extracts of Insects

곤충 생약으로부터 항응고 및 항혈전 물질의 탐색

  • Hahn, Bum-Soo (Natural Products Research Institute, Seoul National University) ;
  • Wu, Song-Ji (Natural Products Research Institute, Seoul National University) ;
  • Kim, Sung-Whan (Department of Food Science and Nutrition, Joongbu University) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University)
  • 한범수 (서울대학교 천연물과학 연구소) ;
  • 우숭지 (서울대학교 천연물과학 연구소) ;
  • 김성환 (중부대학교 식품영양학과) ;
  • 김영식 (서울대학교 천연물과학 연구소)
  • Published : 1999.12.30
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Abstract

The in vitro anticoagulant and fibrinolytic activities of crude extract from insects which have been used as traditional medicines. The extracts of Formica, Huechys and Eupolyph-aga/Steleophaga prolonged activated partial thromboplastin time and thrombin time compared to the value of the control. The fibrinolytic activity of insect extracts was also tested by fibrin plate method. We found that the extracts of Cicadae Periostracum, Eupolyphaga/Steleophdga, Mantidis $O{\ddot{o}}otheca$ and Huechys directly could hydrolyze the fibrin clot without the activation of plasminogen by plasminogen activators.

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