생약학회지 (Korean Journal of Pharmacognosy)
- 제30권4호
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- Pages.413-416
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- 1999
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
쿠마린에 의한 RAW 264.7 세포주의 Nitric Oxide 생성 저해활성
Inhibitory Effect of Coumarins on Nitric Oxide Production in LPS-Activated Murine Macrophages
- 노태철 (생명공학연구소) ;
- 최희철 (생명공학연구소) ;
- 김보연 (생명공학연구소) ;
- 김영호 (충남대학교 약학대학) ;
- 안종석 (생명공학연구소) ;
- 김영국 (생명공학연구소) ;
- 이현선 (생명공학연구소)
- Rho, Tae-Cheol (Korea Research Institute of Bioscience & Biotechnology) ;
- Choi, Hee-Cheol (Korea Research Institute of Bioscience & Biotechnology) ;
- Kim, Bo-Yeon (Korea Research Institute of Bioscience & Biotechnology) ;
- Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
- Ahn, Jong-Seog (Korea Research Institute of Bioscience & Biotechnology) ;
- Kim, Young-Kook (Korea Research Institute of Bioscience & Biotechnology) ;
- Lee, Hyun-Sun (Korea Research Institute of Bioscience & Biotechnology)
- 발행 : 1999.12.30
초록
During the screening for inhibitors on nitric oxide (NO) production in LPS-activated murine macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of Ponciri Fructus. They were identified as imperatorin (10), phellopterin (11) on the basis of spectroscopic methods. The