한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제15권1호
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  • Pages.75-78
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  • 1998
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

2,2'-Azobis (2- amidinopropano) Dihydrochloride(AAPH)의 투여가 쥐의 간기능에 미치는 영향 1. 임상증상 및 혈액 화학치 소견

Effects of Administration of 2,2'-Azobis(2-amidinopropane) Dihydrochloride(AAPH) on Liver Function in Rats 1. Clinical Signs and Blood Chemical Values

  • 강정부 (경상대학교 수의과대학(동물의학 연구소)) ;
  • 손호상 (경상대학교 수의과대학(동물의학 연구소)) ;
  • 김철호 (경상남도 축산진흥연구소)
  • 발행 : 1998.03.01
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초록

This study was performed to estimate the clinical signs and changes of biochemical parameters in rats with hepatic injury induced by the administration of 2, 2'-azobis(2- amidinopropane)dihydrochloride (AAPH) . Minor behavioral change, brittleness of skin hair and decreased volume of water and feed intake were observed in ra% 2 hours after AAPH administration compared to control group. Concentration of serum albumin showed lower than that of control group. However, concentration of total bilirubin has shown higher than that of control group. As time goes on, . serum LDH activity increased significantly compared to control group, but senun CPK activity did not change compared to control group. Passive hemanglutination of $\alpha $-fetoprotein was negative in all the treaDent groups and control group.

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