The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effect of the Rosae laevigatae Fructus extract on the nitric oxide synthase activity and antioxidan action in Rat's corpus cavernosum penis

금앵자(金櫻子) 추출물(抽出物)이 음경해선체(陰莖海線體)의Nitric oxide synthase 활성(活性) 및 항산화효과(抗酸化效果)에 미치는 영향(影響)

  • Kim, Kyung-Dong (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 김경동 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실)
  • Published : 1998.08.30
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Abstract

Rosae laevigatae Fructus extract (RLF) was tested for the effects on the urethral nitric oxide synthase (NOS) activity and Antioxidation in streptozotocin (STZ) induced diabetic rats. RLF was treated firstly into samples, and then STZ induced diabetic rats were set with them. In vitro, the urethral NOS activity was not noted but the type O activity and type conversion ratio of xanthine oxidase and the level of urethral lipid peroxide were decreased in the level of Dose of extract prepared from RLF. In vivo, after the extract was administered to the animal model for fifteen days, the urethral NOS activity increased in STZ induced diabetic rats to the level of normal rats. The content of urethral nitrite and glutathione followed by RLF pre-medicating administration, increased as highly as normal group in compare with the group treated with STZ. The type O activity and type conversion ratio of xanthine oxidase and the level of urethral lipid peroxide followed by RLF pre-medicating administration, decreased as lowly as normal group in compare with the group treated with STZ. In conclusion, the extract of RLF will be able to restore erectile dysfunction of STZ induced diabetic rats.

Keywords

References

  1. 남성성기능장애의 진단과 치료 김세철
  2. 대한비뇨기과학회지 v.31 no.3 당뇨시 발기부전의 原因 신호승;최형기
  3. Am. J. Physiol. v.254 Cholinergic neurotransmission in human corpus cavernosum. I. Responses of isolated tissue Saenz de Tejada, I.;Blanco, R.;Goldstein, L.;Azadzoi, K.;Morenas, A.;Krane, R.J.;Cohen, R.A.
  4. Cardiovasc. Intervent. Radiol. v.11 Pharmacology of penile erection in humans. Adaekan, P.G.;Ratnam, S.S.
  5. Urol. Clin. N. Amer. v.15.1 Local control of penile erection. Saenz de Tejada, I.;Goldstein, I.;Krane, R.J.
  6. J. Urol. v.15.1 Contraction and relaxation induces by some prostanoids in isolated human penile erectile tissue and cavernous artery Hedlund, H.;Andersson, K.E.
  7. New Engl. J. Med. v.320 Impaired neurogenic and endotheilum mediated relaxation of penile smooth muscle from diabetic men with impotince Saenz de Tejada, I.;Goldstein, I.;Azadoi, K.;Krane, R.J.;Cohen, R.H.
  8. Nature v.333 Vascular endothelial cells synthesize nitric oxide from L-arginine Palmer, R.M.J.;Ashton, D.S.;Moncada, S.
  9. N. Engl. J. Med. v.326 Nitric oxides as mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission Rajfer, J.;Aroson, W.J.;Bush, P.A.;Dorey, F.J.;Ignarro, L.J.
  10. J. Urol. v.146 Basal and acetylcholine-stumulated nitric oxide formation mediates relaxation of rabbit cavernous smooth muscle Knispel, H.H.;Goessl, C.;Beckmann, R.
  11. J. Urol. v.147 Endothelium derived nitric oxide and cyclooxygenade products modulate corpus cavernosum smooth muscle tone Azadzoi, K.M.;Kim, N;Browwn, M.L.;Goldstein, I.;Cohen, R.A.;Saenz de Tezada, I.
  12. J. Clin. Invest. v.88 A nitric oxide-like factor mediates nonadrenergic-noncholinegic neuroginic reoaxation of penile corpus cavernosum smooth muscle Kim, N.;Azdzoi, K.M.;Goldstein, I.;Saenz de Tezada, I.
  13. J. Urol. v.147 Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum Bush, P.A.;W.J.;Buga, G.M.;Razfer, J.;Ignarro, L.J.
  14. Br. J. Pharmacol. v.104 The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal muscle Pickard, R.S.;Powel, P.H.;Zar, M.A.
  15. Endocrinology v.136 no.12 Reduction of penile nitric oxide synthase in diabetic BB/WORdp(Type I) and BBZ/WORdp(Type I I) rats with erectile dysfunction Vernet, D.;Cai, L.;Garban, H.;Babbitt, M.L.;Murray, F.T.;Rajfer, J.;Gonzalez, N.F.
  16. 東醫腎系學 杜鎬京
  17. 實用中醫腎病學 徐平
  18. 혜화의학 v.5 no.1 陽痿에 대한 문헌적 고찰 최훈섭;김철중
  19. 中醫男科講座 江海身;康力生
  20. 糖尿病的中西醫結合論治 林蘭(主編)
  21. 本草學 李尙仁
  22. 申氏本草學 申佶求
  23. 中國傳統性治療學 李彪(主編)
  24. Ph. D. thesis Role of nitric oxide in penile erction. Chung, H.C.
  25. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase : Conversion in vitro of the enzyme activity from dehydrogenase (type D) to oxidase (type O) Stirpe, F.;Della Corte, E.
  26. Biochem. v.31 Ca2+/ Calmodulin-dopendent NO synthase Type-1: A biopteroflavoprotein with Ca2+/ Calmodulin-independent diaphorase and reductase Activities Schmidt, H.W.;Smith, R.M.;Nakzne, M.;Murad, F.
  27. J. Pharmacol. v.252 comparison of spectrophotometric and biological assay for nitric oxide and endothelium-derived relaxing factor(EDRF) : Neurospecificity of the diazotiazation reaction for NO and failure to detect EDRF Tracey, W.R.;Linden, J.;Michael, J.P.;Roger, A.J.
  28. Arch. Biochem. Biophys. v.82 Tissue sulfhydryl group Ellman, G.L.
  29. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction Ohkawa, H.;Ohishi, N.;Yaki, K.
  30. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent. Lowry, O.H.;Rosebrough, N.J.;Farr, A.L.;Randall, R.J.
  31. 泌尿器科學 李鶴松
  32. Urol Clin North Am. v.22 no.4 The penis as a vascular organ Chirist, G.J.
  33. 대한한의학회지 v.17 no.2 발기부전 치료의 한의학적 접근 방법에 관한 연구 송봉근
  34. J. Biol. Chem. v.267 no.16 Nitric oxide synthase regulatory setes. Bredt, D.S.;Ferris, C.D.;Snyder, S.H.
  35. Ann. Neurol. v.32 A novel neuronal messenger molecule in brain : The free radical, nitric oxide Dawson, T.M.;Dawson, V.L.;Snyder, S.H.
  36. 中醫治療內分泌代謝病 余永譜
  37. 中醫臨床大全 楊思澍(外)
  38. 益壽延年 二百方 盧祥之(編著)
  39. 男科中成藥便覽 許國振(編著)
  40. 東醫寶鑑 許俊
  41. 景岳全書 張景岳
  42. 本草綱目 v.5 no.부록 李時珍
  43. 普濟方 周王朱橚(撰)
  44. J. Biol. Chem. v.245 A mechanism for the production of ethylene from methional : The generation of the hydroxyl radical by xanthine oxidase Beauchamp, C.;Fridovich, I.
  45. Comp. Biochem. Physiol. v.49B A comparison of the distribution and electron acceptor specificities of xanthine oxidase and aldehyde oxidase Kreintsky, T.A.;Tuttle, J.V.;Cattau, E.L.;Wang, P.
  46. Lipids v.11 Autoxidation of polyunsaturated fatty acids(II) Pryor, W.A.;Stanley, T.P.;Blair, E.
  47. Pharmacol. Ther. v.37 no.2 Glutathione, free radicals and chemotherapeutic agents : Mechanism of free radical induced toxicity and glutathione dependent protection Ross, D.
  48. Adv. Enzymol. v.32 The role of glutathione and glutathione S-transferase in mercapturic acid biosynthesis. Boyland, E.;Chasseud, L.F.
  49. J.Pharm. pharmacol. v.41 Mechanistic toxicology: A radical perspective David, R.
  50. FASEB. J. v.1 Oxidants and human disease : Some new concepts Barry, H.