생약학회지 (Korean Journal of Pharmacognosy)
- 제29권2호
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- Pages.120-124
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- 1998
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Aloe속 식물의 고분자물질 분획이 알콜대사에 미치는 효과
Effects of High Molecular Weight Fractions of Aloe spp. on Alcohol Metabolism
- 한용남 (서울대학교 천연물과학연구소) ;
- 정하숙 (서울대학교 천연물과학연구소) ;
-
임순성
(서울대학교 천연물과학연구소) ;
- 이상현 (서울대학교 천연물과학연구소) ;
- 심창섭 ((주) 김정문알로에 중앙연구소) ;
-
신국현
(서울대학교 천연물과학연구소)
- Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
- Chung, Ha-Sook (Natural Products Research Institute, Seoul National University) ;
-
Lim, Soon-Sung
(Natural Products Research Institute, Seoul National University) ;
- Lee, Sang-Hyun (Natural Products Research Institute, Seoul National University) ;
- Shim, Chang-Sub (R & D Center, Kim Jeong Moon Aloe Co., LTD.) ;
-
Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul National University)
- 발행 : 1998.06.30
초록
For the purpose of evaluating protective components against alcohol-induced toxicity, the active components enhancing alcohol metabolism was pursued from water soluble fraction by ethanol precipitation and DEAE-cellulose chromatographic technique. As a result, various high molecular weight fractions from Aloe vera and Aloe arborescens, on a single oral administration in rats were found to cause a significant decrease in the blood ethanol concentration as well as enhancement of liver cytosolic ADH and ALDH activities and among which, a strong acidic high molecular weight fraction was demonstrated to exhibit the most potent enhancing activity on ethanol metabolism.
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