Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
권호 표지

Expression of nm23 in Mucosal Melanoma of the Head and Neck

두경부에 발생한 점막형 악성흑색종에서 nm23의 발현양상

  • Choi Jong-Ouck (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University) ;
  • Chung Leun (Department of Otorhinolaryngology, College of Medicine, Hallym University) ;
  • Min Hun-Ki (Department of Otorhinolaryngology, College of Medicine, Hallym University) ;
  • Kim Yong-Hoan (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University) ;
  • Lee Seung-Hoon (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University) ;
  • Choi Geon (Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, Korea University)
  • 최종욱 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
  • 정근 (한림대학교 의과대학 이비인후과학교실) ;
  • 민헌기 (한림대학교 의과대학 이비인후과학교실) ;
  • 김용환 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
  • 이승훈 (고려대학교 의과대학 이비인후-두경부외과학교실) ;
  • 최건 (고려대학교 의과대학 이비인후-두경부외과학교실)
  • Published : 1997.05.01
Download PDF
⟨ Previous Next ⟩

Abstract

Malignant melanoma has a very poor prognosis compared to other cancers. There are no specific tumor markers other than clinical staging and depth of invasion to predict the prognosis of the malignant melanoma. The nm23 has been known to inhibit the metastasis of the malignant melanoma, some studies showed that it is highly expressed in the malignant melanoma cell line which has a relatively weak metastatic potential. In this study, we compared the expression of nm23 in mucosal type with that in cutaneous type of the malignant melanoma in the head and neck according to the stage and survival rate to identify the role of nm23 expression as a prognostic factor in mucosal melanoma of the head and neck. Six out of eight cases in mucosal type and seven out of 11 cases in cutaneous type expressed nm23, which showed no significant differences. Between the two groups there were no significant differences in expression of nm23 according to clinicopathologic staging or two year survival rate. However, in cases with low cliniopathological staging and those surviving more than two years the expression was significantly increased which suggests that expression of nm23 can be used as an aid in determining the prognosis of mucosal melanoma.

Keywords