YAKHAK HOEJI (약학회지)
- Volume 40 Issue 1
- /
- Pages.46-51
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- 1996
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- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Synthesis of D-1,3-Dioxolane and L-1,3-Oxathiolane 5-Phenylselenyl Pyrimidine Nucleosides as Potential Antiviral Agents
D-1,3-디옥솔란 및 L-1,3-옥사티올란 5-페닐세레닐 피리미딘 뉴크레오사이드의 합성
- Yoo, Jung-Man (College of Pharmacy, Chonnam National University) ;
- Moon, Hyun-Ju (College of Pharmacy, Chonnam National University) ;
- Chung, Byung-Ho (College of Pharmacy, Chonnam National University) ;
- Choi, Bo-Gil (College of Pharmacy, Chonnam National University) ;
-
Hong, Joong-Hee
(College of Pharmacy, Seuol National University)
;
- Chun, Moon-Woo (College of Pharmacy, Seuol National University)
- 유정만 (전남대학교 약학대학) ;
- 문현주 (전남대학교 약학대학) ;
- 정병호 (전남대학교 약학대학) ;
- 최보길 (전남대학교 약학대학) ;
-
홍준희
(서울대학교 약학대학)
;
- 천문우 (서울대학교 약학대학)
- Published : 1996.02.01
Abstract
Eight new D-1.3-dioxolanyl and L-1,3-oxathiolanyl nucleosides containing 5-phenyl- selenyl pyrimidine bases which are expected to have antiviral activity were synthesized. Condensation of D-1,3-dioxolane acetate and L-1,3-oxathiolane acetate with 5-phenylselenyl pyrimidines gave anomeric mixtures of their nucleosides which were separated by silicagel column chromatography.
Keywords
- Antiviral agent;
- D-1,3-dioxolanyl acetate;
- L-1,3-Oxathiolane;
- 5-Phenylselenyluracil nucleosides;
- 5-Phenylselenyl-6-azauracil nucleosides