• Title/Summary/Keyword: D-1,3-dioxolanyl acetate

Search Result 2, Processing Time 0.016 seconds

Synthesis of D-1,3-Dioxolane and D-1,3-Oxathiolane Pyrimidine Nucleosides (D-1,3-Dioxolane 및 D-1,3-Oxathiolane 피리미딘 뉴크레오사이드의 합성)

  • Hong, Joon-Hee;Cha, Ma-Rie;Shin, Seong-Eun;Choi, Bo-Gil;Chung, Byung-Ho;Kim, Joong-Hyup;Lee, Chong-Kyo;Chung, Won-Keun;Chun, Moon-Woo
    • YAKHAK HOEJI
    • /
    • v.38 no.6
    • /
    • pp.703-711
    • /
    • 1994
  • We synthesized D-1,3-dioxolanyl acetate from D-mannose using Frazer-Reide reaction and D-1,3-oxathiolanyl acetate from either D-mannose or D-galactose in good yields. These acetates were conjugated with various disilylated pyrimidine base using trimethylsilyl trifluoromethane sulfonate as a Lewis acid catalyst to obtain 32 different D-nucleosides.

  • PDF

Synthesis of D-1,3-Dioxolane and L-1,3-Oxathiolane 5-Phenylselenyl Pyrimidine Nucleosides as Potential Antiviral Agents (D-1,3-디옥솔란 및 L-1,3-옥사티올란 5-페닐세레닐 피리미딘 뉴크레오사이드의 합성)

  • Yoo, Jung-Man;Moon, Hyun-Ju;Chung, Byung-Ho;Choi, Bo-Gil;Hong, Joong-Hee;Chun, Moon-Woo
    • YAKHAK HOEJI
    • /
    • v.40 no.1
    • /
    • pp.46-51
    • /
    • 1996
  • Eight new D-1.3-dioxolanyl and L-1,3-oxathiolanyl nucleosides containing 5-phenyl- selenyl pyrimidine bases which are expected to have antiviral activity were synthesized. Condensation of D-1,3-dioxolane acetate and L-1,3-oxathiolane acetate with 5-phenylselenyl pyrimidines gave anomeric mixtures of their nucleosides which were separated by silicagel column chromatography.

  • PDF