Korean Journal of Animal Reproduction (한국가축번식학회지)

The Korean Society of Animal Reproduction (한국동물번식학회)
권호 표지

The Effect of Leonurus sibiricus on Uterine Activity

익모초(Leonurus sibiricus)가 자궁운동에 미치는 영향

  • Pak, S.C. (Research Division of Biological Science, College of Medicine, Chosun University) ;
  • Na, H.M. (Research Division of Biological Science, College of Medicine, Chosun University) ;
  • Bai, Y.H. (Research Division of Biological Science, College of Medicine, Chosun University) ;
  • Cho, C. (Research Division of Biological Science, College of Medicine, Chosun University) ;
  • Na, C.S. (Dept. of Oriental Medicine, College of Medicine, Dongshin University) ;
  • Kim, J.S. (Dept. of Oriental Medicine, College of Medicine, Dongshin University) ;
  • Wilson Jr., L. (Dept. of Obstetrics & Gynecology, Univ. of Illinois at Chicago)
  • 박석천 (조선대학교 의과대학 생물학교실) ;
  • 나호민 (조선대학교 의과대학 생물학교실) ;
  • 배영훈 (조선대학교 의과대학 생물학교실) ;
  • 조징 (조선대학교 의과대학 생물학교실) ;
  • 나창수 (동신대학교 한의과대학 한의학과) ;
  • 김정상 (동신대학교 한의과대학 한의학과) ;
  • Published : 1996.02.01
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Abstract

This study was undertaken to illustrate the uterotonic effect of Leonurus sibiricus. It was dissolved in sterile water and several different dosages were administered both in vitro and in vivo study. Rat uterine tissue for in vitro bioassay was obtained from estrous rat. From the low to high dosages of Leonurus sibiricus were tried and each uterine contraction was recorded and integrated. Anesthetized estrous rat for in vivo study was cannulated into the jugular vein for infusion of the compound. Another cannula with a balloon tipped and water filled was inserted into the uterus to measure uterine activity. While the uterine tissue did not respond to low dosage of compound, high dosage of compound stimulated the tissue to contract less than 1 minute with low amplitude. In vivo rat uterus showed a certain, consistent pattern of contractions which was initial relaxation and followed by prolonged and increased amplitude of contractions. It also caused a short breathing stop which might be due to acute acidosis.

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