Korean Journal of Psychosomatic Medicine (정신신체의학)

Korean Psychosomatic Society (한국정신신체의학회)
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Double-blind Comparative Trial of Fluoxetine and Amitriptyline in Major Depression

주요우울증에서 Fluoxetine과 Amitriptyline의 치료효과에 대한 이중맹검법 비교연구

  • Jung, Hee-Yeon (Department of Psychiatry, Seoul City Boramae Hospital) ;
  • Bae, Jae-Nam (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Kwon, Jun-Soo (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Cho, Doo-Young (Department of Neuropsychiatry, Seoul National University Hospital)
  • 정희연 (서울특별시립 보라매병원 정신과) ;
  • 배재남 (서울대학교병원 신경정신과학교실) ;
  • 권준수 (서울대학교병원 신경정신과학교실) ;
  • 조두영 (서울대학교병원 신경정신과학교실)
  • Published : 1995.06.15
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Abstract

The efficacy of fluoxetine was evaluated in 32 patients with major depression in double-blind amitriptyline-controlled clinical trials. Patients were randomly assigned to 6 weeks of treatment with 20mg/day of fluoxetine and 25-100mg/day of amitriptyline. We used the Hamilton rating scale for depression(HAM-D) and the Clinical Global Improvement(CGI) to evaluate the improvement of depression. In addition, we also used the Covi Anxiety Scale and the Anxiety/Somatization subscale of HAM-D to investigate the relieving effect of anxiety. The improvement by fluoxetine in mean total score of HAM-D and CGI was comparable to amitriptyline. Fluoxetine also reduced anxiety significantly, but there was no difference between fluoxetine and amitriptyline in relieving anxiety symptoms. Fluoxetine showed considerably less adverse effects, especially anticholinergic effect and weight gain than amitriptyline. In conclusion, 20mg/day of fluoxetine was sufficiently effective in the treatment of depressive patients and was better tolerated than amitriptyline.

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Acknowledgement

Supported by : 서울대학교병원