동아시아식생활학회지 (Journal of the East Asian Society of Dietary Life)

  • 제5권3호
  • /
  • Pages.215-221
  • /
  • 1995
  • /
  • 1225-6781(pISSN)
  • /
  • 2288-8802(eISSN)
동아시아식생활학회 (The East Asian Society of Dietary Life)
권호 표지

포공영 추출물이 흰쥐간 Xanthine Oxidase 활성에 미치는 영향

Effect of Taraxacum herba Extract on the Hepatic Xanthine Oxidase Activity in Rats

  • 이상일 (계명전문대학 식품영양과) ;
  • 이영순 (계명전문대학 식품영양과) ;
  • 윤종국 (계명대학교 자연과학대학 공중보 건학과)
  • 발행 : 1995.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study was undertaken to investigate the effect of Taraxacum herba extract on the hepatic xanthine oxidase activity as a oxygen free radical generating enzyme in vitro and in vivo. It was observed that partial purified hepatic xanthine oxidase (type O) activity was strongly inhibited by the addition of Taraxacum herba n-butanol extract in vitro. The Km value of xanthine oxidase without affecting the Vmax value for xanthine was significantly increased by the addition of ta-dase (type O) activity was significantly inhibited by the treatment of Taraxacum gerba n-butanol ex-tract for 5days(over 40mg/kg, i.p), whereas, xanthine oxidase (type D) activity was not changed by the injection of Taracacum herba n-butanol extract. Meanwhile, liver weight / body weight(%), serum alanine aminotransferase activity and hepatic lipid peroxide content in Taraxacum herba n-buta-nol extract-treated rat were not changed. These findings led us to conclude that Taraxacum herba n-butanol extract may regulate the hepatic xanthine oxidase type O activity to prevent toxic effect of oxidative stress by the oxygen free radicals.

키워드

참고문헌

  1. 圖說漢方醫藥大事典(中國醫藥事典) v.1 陳存仁
  2. 현대 생약학 한덕룡
  3. Biochem. J. v.20 The distribution of xanthine oxidase Morgen,E.J.
  4. Biochem. J. v.97 The species distribution of xanthine oxidase Al-Khalidi,U.A.E.;Chaglassian,T.H.
  5. J. Bacteriol. v.130 Distribution of xanthine oxidase and xanthine dehydrogenase specific types among bacteria Woolfolk,C.A.;Downard,J.S.
  6. J. Biol. Chem. v.244 The regulation of rat liver xanthine oxidase Stirpe,F.;Della Corte, E.
  7. Biochem. J. v.126 Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat Battlli,M.G.;Della Corte, E.;Stripe,F.
  8. J. Biol. Chem. v.226 Pyrazolopyrimidines as a inhibitors and substrates of xanthine oxidase Feigelson,P.;Daivision,J.D.;Robins,R.K.
  9. J. Lab. Clin. Med. v.74 A sensitive and nonradioactive assay for serum and tissue xanthine oxidase Ramboer,C.R.H.
  10. Biochem. J. v.131 Characterization of alternative molecular forms of xanthine oxidase in the mouse Duke,E.J.;Toyce,P.;Ryan,J.P.
  11. J. Biol. Chem. v.243 The reduction of cytochrome C by milk xanthine oxidase Mccord,J.M.;Fridovich,I.
  12. Infec. Immun. v.3 Induction of xanthine oxidase by virus infections in newborn mice Ziegler,D.W.;Huntchinson,H.D.;Kissling,R.E.
  13. Arzneim Frosch.(Drug. Res.) v.26 Xanthine oxidase activation in animal liver during infectious processes Tubaro,E.;Banci,F.;Lotti,B.;Crose,C.
  14. Biochem. Pharmacol. v.29 Liver xanthine oxidase increase in mice in three pathological models Tubaro,E.;Lotti,B.;Croce,C.;Caballo,G.;Borelli,G.
  15. Am. Intern. Med. v.89 The biology and pathology oxygen radicals McCord,J.M.;Fridovich,I.
  16. Can. J. Physiol. Pharmacol. v.60 The pathophysiology of superoxide : Roles in inflammation and ischemia McCord,J.M.;Roys,R.S.
  17. Comp. Biochem. Physiol. v.498 A comparison of the distribution and electron acceptor specificities of xanthine oxidase and aldehyde oxidase Kleinsky,T.A.;tulle,J.V.;Cattau,E.L.;Wang,P.
  18. Biochem. Biophys. Acta v.762 Myocardial xanthine oxidase/dehydrogenase Schoutsen,B.;De Jong, J. W.;Harmsen,E.;De Tombe, P. P.;Achterberg,P.W.
  19. Acta physiol. Scand.(Suppl.) v.548 Significance of xanthine oxidase in capillary endothelial cells Jarasch,E.D.;Bruder,G.;Heid,H.W.
  20. J. Biol. Chem. v.264 Characterization of free radical generation by xanthine oxidase Periannan,K.;Jay,L.Z.
  21. Chem. Pharm. Bull. v.4 Chemical studies on the oriental plant drugs XVⅡ : The prosapogenin of the ginseng saponins (Ginsenosides-Rb₁,-Rb₂,-Rc) Shibata,S.;Ando,T.;Tanaka,O.
  22. J. Biol. Chem. v.241 The mechanism of dietary alterations in rat Hepatic xanthine oxidase levels Rowe,P.B.;Wyngaarden,J.B.
  23. Am. J. Clin. Pahtol. v.28 A colorimetric method for the determination of serum oxalacetic and glutamic pyruvic transaminase Reitman,S.;Frankel,S.
  24. Anal. Biochem. v.95 Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction Ohkawa,H.;Ohishi,N.;Yaki,K.
  25. J. Biol. Chem. v.193 Protein measurement with folin phenol reagent Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.;Randall,R.J.
  26. Proc. Exp. Biol. Med. v.91 Serum glutamic pyruvic transaminase in cardiac and hypatic disease Wroblewski,F.;La Due. J. S.
  27. J. Biol. Chem. v.239 The biochemistry of animal cells : The effect of corticosteroids on leakage of enzyme from dispersed rat liver cells Takeda,Y.;Ichihara,A.;Tanioka,H.;Inove,H.
  28. Am. Rev. Toxicol. Pharmacol. v.16 Chemicals, drugs and lipid peroxidation Plaa,G.L.;Witschin,H.