Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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First-Pass Observation using Tailored-RF Gradient Echo (TRFGE) MR Imaging in Cat Brain

자기공명 Tailored-RF 경사자계반향영상법을 이용한 고양이 뇌에서의 First-Pass관찰

  • 문치웅 (아산생명과학연구소 방사선의학연구과) ;
  • 노용만 (대전대학교 컴퓨터공학과, 울산대학교 의과대학, 서울중앙병원, 진단방사선과, 한국과학기술원, 정보통신공학과)
  • Published : 1995.06.01
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Abstract

Recently, a new tailored RF gradient echo (TRFGE) sequence was reported. This technique not only enhances the magnetic susceptibility effect but also allows us to measure local changes in brain oxygenation. In this study, a phantom and cat brain experiments were performed on a 4.7 Tesla BIQSPEC (BRUKER) instrument with a 26 cm gradient system. We have demonstrated that the signal intensity (SI) of the TRFGE sequence varies according to the concentration of susceptibility contrast agent. Three capillary tubes with different concentrations of Gd-DTPA (0.01, 0.05, 0.1 mMOI/l) were placed at the middle of a cylindrical water phantom. Using both TRFGE and conventional gradient echo (CGE) sequences, phantom images of the slices which contain all three tubes were obtained. For the animal experiment, cats were anesthetized and ventilated using halotane (0.5%) and a $N_2O/ O_2$ mixture (2:1), and blood pressure and heart rate were monitored and kept normal. For the observation of tue first pass of Gd- DTPA, imaging was started at t = 0. At t = 8 ~ 12s, 0.2 mMol/Kg Gd-DTPA was manually injected in the femoral vein. The imaging parameters were TRITE = 25/10 msec, flip angle = $30^{\circ}$, FOV = 10cm, image matrix size = $128{\times}128$ with 64 phase encodings and the image data acquisition window was 10 msec. SI-time curves were then obtained from a series of 30 images which were collected at 2 sec intervals using both CGE and TRFGE pulse sequences before, during, and following the contrast injection.

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