Studies on Controlled Release of Indomethacin from PVA Hydrogel

The polyvinyl alcohol (PVA) hydrogel containing 1-methy-2-pymolidinone (MP) and sorbitol was preapred by the freeze and thaw method. The release rate of indomethacin from PVA hydrogel was used as a criterion for deciding the optimum formula of hydrogel using the computer optimization technique. The hydrogel of optimum formula was composed of PVA (10 w/v%), MP (0 w/v%) and sorbitol (40 w/v%) and the release rate of indomethacin was 1.981$\mu$g/ml$\cdot{min}^{1/2}$.