Archives of Pharmacal Research
- 제16권1호
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- Pages.36-42
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Toxic Components of Auricularia polytricha
- Kim, Ha-Won (Department of Microbial Chemistry, College of Pharmacy, Seoul National University)
- 발행 : 1993.03.01
초록
To find biologically active components of the higher fungi of Korea, the carpophores of Auricularia polytricha, a well-known edible mushroom, were extracted with 0.14 M NaCl solution. The extract was successively fractionated by adding ammonium sulfate at various concentrations, and the respective precipitates were separated by centrifugation, then dialyzed and freeze-dried. When a does of 60 mg/kg of each was injected i.p. into ICR mice, the fraction which precipitated at 20% ammonium sulfate showed the highest toxicity, killing seven out of seven mice within two days. The fraction obtained at 40% ammonium sulfate showed the second highest toxicity. The two fractions were named auritoxin I and II after the genus name. However, they Nere shown to have nearly identical composition by physicochemical and 6.8% protein. The polysaccharide moiety was found to have 12.3%
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