Archives of Pharmacal Research
- 제16권1호
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- Pages.50-56
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- 1993
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Studies on the Development for Sustained Release Preparation (II):Preparation and Evaluation of Eudragit Microcapsules of Sodium Naproxen
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Shin, Sang-Chul
(College of Pharmacy, Chonnam National University) ;
- Lee, Keong-Ran (College of Pharmacy, Chonnam National University)
- 발행 : 1993.03.01
초록
The microencapsulation of sodium naproxen with Eudragit. RS was studied by coacrtvation/phase separation process using Span 80 in mineral oil/acetone system. Various factors which affect the mciroencapsulation, e.g., stirring speed, and surfactant concentraction, Eudagit RS concentration and loading drug amounts were examined. For the evaluation of the prepared microcapsules, release rate, particle size distribution and surface appearance as well as in vivo test were carried out. The addition of n-hexane and freezing of microcapsules accelerated the hardening of microcapsules. The optimum concentration of Span 80 ti prepare the smallest microcapsules was the same value with the CMC of Span 80 in solvent system. When 1.5% (w/w) Span 80 was used, the smallest microcapsules were formed