Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Further Study on the Anti-hypercholesterolemic Effect of Ixeris sonchifolia

고들빼기의 고콜레스테롤혈증 개선효과

  • Young, Han-Suk (College of Pharmacy, Pusan National University) ;
  • Choi, Jae-Sue (Dept. of Nutrition and Food Science, National Fisheries University of Pusan) ;
  • Lee, Ji-Hyon (Dept. of Nutrition and Food Science, National Fisheries University of Pusan)
  • 양한석 (부산대학교 약학과) ;
  • 최재수 (부산수산대학교 식품영양학과) ;
  • 이지현 (부산수산대학교 식품영양학과)
  • Published : 1992.06.30
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Abstract

Effect of various fractions prepared from the methanol extract of Ixeris sonchifolia and flavonoids isolated from the extract on hypercholesterolemic mice were examined. When various fractions $(CHCl_3,\;Interphase,\;EtOAc,\;n-BuOH\;and\;H_2O)$were administered to mice, the Interphase material produced a significant activity. Total cholesterol level in the Interphase material-treated group given doses of 25 and 50mg was decreased significantly by as much as 16% and 30%, respectively. Among the isolated flavonoids, cynaroside caused a significant hypocholesterolemic activity.

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