YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Production of Monoclonal Antibody against the Principal Metabolite of Cocaine, Benzoylecgonine

코카인의 주대사물인 벤조일에코닌에 대한 단일클론 항체의 제작

  • Nam, Kyung-Soo (Laboratory of Immunochemistry, Genetic Engineering Research Institute, KIST) ;
  • Kim, Jae-Wha (Laboratory of Immunochemistry, Genetic Engineering Research Institute, KIST) ;
  • Oh, Eun-Suk (Laboratory of Immunochemistry, Genetic Engineering Research Institute, KIST) ;
  • Choi, Myung-Ja (Dopping Control Center, KIST) ;
  • Choi, In-Seong (Laboratory of Immunochemistry, Genetic Engineering Research Institute, KIST) ;
  • Chung, Tai-Wha (Laboratory of Immunochemistry, Genetic Engineering Research Institute, KIST)
  • 남경수 (KIST 유전공학연구소, 면역화학연구실) ;
  • 김재화 (KIST 유전공학연구소, 면역화학연구실) ;
  • 오은숙 (KIST 유전공학연구소, 면역화학연구실) ;
  • 최명자 (KIST 도핑콘트롤 센타) ;
  • 최인성 (KIST 유전공학연구소, 면역화학연구실) ;
  • 정태화 (KIST 유전공학연구소, 면역화학연구실)
  • Published : 1992.04.29
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Abstract

Two clones of monconal antibodies(Co-1 and Co-2) against BSA-benzoylecgonine(BSABE) were produced. Both monoclonal antibodies showed high binding affinity to BSA-BE. Observing from ELISA inhibition assay, Co-1 reacted only weakly with soluble benzoylecgonine, while Co-2 showed considerable reactivity with soluble benzoylecgonine.

Keywords