Archives of Pharmacal Research
- 제14권2호
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- Pages.130-136
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- 1991
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Role of Cytochrome P-450 in the Bioactivation of Nicotine
- Kim, Bong-Hee (College of Pharmacy, Chung Nam National University) ;
- Anthony Travor (Department of Pharmacology and Division of Toxicology)
- 발행 : 1991.06.01
초록
Nicotine (100 .mu. M) was incubated with microsomes (1 mg/ml) prepared from New Zealand White rabbits. On the basis of microsomal weight, the rate of nicotine oxidation were calculated on the basis of cytochrome P-450 concentration, the specific activity of the metabolic oxidation catalyzed by lung was approximately 4 times greater than liver (6.4 vs 1, 65 nmoles nicotine oxidized. nmole cytochrome
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