Journal of Pharmaceutical Investigation
- Volume 18 Issue 2
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- Pages.61-67
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- 1988
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effects of Suppository Bases on Bioavailability of Aspirin Suppositories
좌제기제가 아스피린 좌제의 생체내이용율에 미치는 영향
- Kim, Yong-Hyun (College of Pharmacy, Chosun University) ;
- Lee, Jin-Hwan (College of Pharmacy, Chosun University) ;
- Choi, Jun-Shik (College of Pharmacy, Chosun University)
- Published : 1988.06.20
Abstract
The influence of different suppository bases on the dissolution, and the bioavailability of aspirin suppositories in rabbits and humans was investigated using Witepsol H15 (WIT), WIT-Tween 80 (TWE), WIT-sodium lauryl sulfate (SLS), polyethylene glycol (PEG), hollow WIT (WIT-HOLL) and capsule incorporated into WIT (WIT-CAP). The results obtained were as follows: 1) Dissolution rates of aspirin suppositories with different bases in distilled water were faster in the order of WIT-TWE >WIT-SLS >PEG >WIT-HOLL >WIT >WIT-CAP. 2) The maximum blood levels
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