Journal of Pharmaceutical Investigation
- Volume 3 Issue 1_2
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- Pages.16-22
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- 1973
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Microbiological Quantitative Assay of Pivampicillin.HCl
Pivampicillin.HCl에 관(關)한 연구(硏究) I -미생물학적(微生物學的) 정량법(定量法)-
- Lee, Han-Pyo (Dai-Han Jungoe Pharmaceutical Co.) ;
- Kim, Chung-Kyu (Dai-Han Jungoe Pharmaceutical Co.) ;
- Sim, Young-Ki (Dai-Han Jungoe Pharmaceutical Co.) ;
- Yong, Kun-Ho (National Institute of Health)
- Published : 1973.03.20
Abstract
Biological determination of Pivampicillin hydrochloride was examined and an available method has been established. Unhydrolyzed Pivampicillin hydrochloride has no antibacterial activity, but it exhibits an antibacterial activity hydrolyzed with liberation of ampicillin by nonspecific enzymes present in blood and tissues from various species in vitro and in vivo. Using these properties, Pivampicillin hydrochloride can be determined as ampicillin by use of an agar-diffusion method with Bacillus subtilis as the assay organism.
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