Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Influence of Atractylis on the Renal Function of the Dog

창출(蒼朮)이 개의 신장기능(腎臟機能)에 미치는 영향(影響)

  • Ko, Suk-Tai (Dept. of Pharmacology, College of Pharmacy, Cho Sun University) ;
  • Kim, Sung-Oh (Dept. of Pharmacology, College of Pharmacy, Cho Sun University)
  • 고석태 (조선대학교약학대학 약물학교실) ;
  • 김성오 (조선대학교약학대학 약물학교실)
  • Published : 1973.03.20
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Abstract

The effect of atractylis on the renal function of the dog was investigated in this study. Alcohol extract of atractylis, when given intravenously in dose 15mg/kg, elicited antidiuresis rather than diuresis. Also, free water clearance $(C_{H_2O})$ decreased in proportion. No alterations of the renal clearances of creatinine and PAH were detected in the range of doses which are effective in inhibiting diuresis. The effects were obtained with smaller doses when the atractylis was given through the intracarotid artery route rather than intravenously. When infused directly into a renal artery, atratylis exhibited identical action on both kidneys, indicating that the renotropic action is mediated by some endogenous humoral agents. It is therefore suggested that atractylis is capable of releasing ADH from the neurohypophysis.

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