Bio-degradable 3D-scaffold fabrication using rapid-prototyping system

쾌속조형시스템을 이용한 생체 조직 재생용 지지체 제작과 특성분석

The purpose of tissue engineering is to repair or replace damaged tissues or organs by a combination of cells, scaffold, suitable biochemical and physio-chemical factors. Among the three components, the biodegradable scaffold plays an important role in cell attachment and migration. In this study, we designed 3D porous scaffold by Rapid Prototyping (RP) system and fabricated layer-by-layer 3D structure using Polycarprolactone (PCL) - one of the most flexible biodegradable polymer. Furthermore, the physical and mechanical properties of the scaffolds were evaluated by changing the pore size and the strand diameter of the scaffold. We changed nozzle diameter (strand diameter) and strand to strand distance (pore size) to find the effect on the mechanical property of the scaffold. And the surface morphology, inner structure and storage modulus of PCL scaffold were analyzed with SEM, Micro-CT and DMA.