Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Protective agents against sepsis from the root bark of Paeonia suffruticosa

  • Li-Gao (College of Pharmacy, Yeungnam University) ;
  • Xu , Ming-Lu (Department of Pharmacology, Hallym University College of Medicin) ;
  • Seo, Chang-Seob (Department of Pharmacology, Hallym University College of Medicin) ;
  • Kim, Hyo-Jin (Department of Pharmacology, Hallym University College of Medicin) ;
  • Lee, You-Jeong (Department of Pharmacology, Hallym University College of Medicin) ;
  • Lee, Yeun-Koung (Department of Pharmacology, Hallym University College of Medicin) ;
  • Son, Jong-Keun (Department of Pharmacology, Hallym University College of Medicin) ;
  • Song, Dong-Keun (Department of Pharmacology, Hallym University College of Medicine)
  • Published : 2003.10.01
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Abstract

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root bark of Paeonia suffruticosa led to the isolation of ten known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2) methyl 3-hydroxy-4- methoxybenzoate (3), acetovanillone (4), benzoic acid (5), benzoylpaeoniflorin (6), paeonoside (7), paeoniflorin (8), oxypaeoniflorin (9) and apiopaeonoside (10). Among them, 4 exhibited the highest survival rate in a dose-dependent manner (100% with a dose of 30 mg/kg versus 16.7% for the control experiment) and showed reduction of plasma alanine aminotransferase (ALT) value on the in vivo assay model of sepsis induced by LPS/GalN.

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