Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.199.1-199.1
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- 2003
Inhibitory Effects of Manassantin A and B Isolated from the Roots of Saururus chinensis on PMA-Induced ICAM-l Expression
- Eok, Kwon-Oh (Korea Research Institute of Bioscience and Biotechnology) ;
- Lee, Seung-Woong (College of Pharmacy, Chungnam National University) ;
- Chung, Mi-Yeon (College of Pharmacy, Chungnam National University) ;
- Kim, Young-Ho (College of Pharmacy, Chungnam National University) ;
- Kim, Koan-Hoi (College of Pharmacy, Chungnam National University) ;
- Rho, Mun-Chual (College of Pharmacy, Chungnam National University) ;
- Lee, Hyun-Sun (College of Pharmacy, Chungnam National University) ;
- Kim, Young-Kook (College of Pharmacy, Chungnam National University)
- Published : 2003.10.01
Abstract
In the course of our search for intercellular adhesion molecule-1 (ICAM-1)/leukocyte function-associated antigen-1 (LFA-1) mediated cell adhesion inhibitors from natural sources, new type of cell adhesion inhibitors were isolated from the MeOH extract of Saururus chinensis roots. On the basis of spectral evidence, the structures of the active compounds were identified as manassantin A and B. Manassantin A and B inhibited phorbol 12-myristate 13-acetate (PMA)-induced homotypic aggregation of the human promyelocytic leukemia HL-60 cells without cytotoxicity with MIC value of 1.0 and 5.5 nM, respectively. (omitted)
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