Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.98.1-98.1
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- 2003
Anti-inflammatory mechanism of bee vemon in Raw 264.7 cells and Synoviocyte
- Hwang, In-Young (College of Pharmacy, Chungbuk National University) ;
- Park, Hye-Ji (College of oriental Medicine, Kyungwon University) ;
- Kim, Kee-Hyun (KRIB) ;
- Lee, Seung-Ho (KRIB) ;
- Oh, Goo-Taeg (KRIB) ;
- Hong, Jin-Tae (KRIBB)
- Published : 2003.10.01
Abstract
Bee venom (BY) has been utilized to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis (RA). However, the molecular mechanism by which BV-induced anti-arthritis effect has been not reported yet. Therefore, in the present study we investigated anti-inflammatory effect of BV in a murine marcrophage cell line Raw 264.7 cell and synoviocyte obtained from RA patients. The present data showed that BV has a preventive effect on lipopolysaccharide (LPS) and sodium nitroprusside (SNP) induced induction of COX-2, cPLA2 and iNOS. (omitted)
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