Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells

  • Kim, Eung-Il (College of Pharmacy, Chungbuk National University) ;
  • Yoo, Seung-Hee (College of Pharmacy, Chungbuk National University) ;
  • Kim, Yu-Mi (College of Pharmacy, Chungbuk National University) ;
  • Lee, Jae-Joon (College of Pharmacy, Chungbuk National University) ;
  • Kang, Min-Hee (College of Pharmacy, Chungbuk National University) ;
  • Lee, Myung-Koo (College of Pharmacy, Chungbuk National University)
  • Published : 2003.10.01
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Abstract

The inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells were investigated. Tetrahydropapaverine at concentration ranges of 5-20 M decreased serotonin content in a concentration-dependent manner in P815 cells and showed 42.1 % inhibition of serotonin content at 5.0 M for 24 hr. The value of 50 % inhibitory concentration, IC$\sub$50/, of tetrahydropapaverine was 6.2 M. Under these conditions, tryptophan hydroxylase (EC 1.14.16.4, TPH), was inhibited for 24-36 hr after treatment with tetrahydropapaverine in P815 cells(49.1 % inhibition at 7.5 M). (omitted)

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