Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Enhanced in vitro/in vivo Characteristics of Glucagon-like Peptide-1 by PEGylation

  • Han, H.S. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Youn, Y.S. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Oh, S.H. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Hong, S.T. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Lee, J.E. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Lee, S.O. (Drug Targeting Laboratory, SungKyunKwan University) ;
  • Lee, K.C. (Drug Targeting Laboratory, SungKyunKwan University,)
  • Published : 2003.04.01
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Abstract

The insulinotropic hormone, glucagons-like peptide-1 (GLP-1), which has been proposed as a new potential therapeutics for type-II diabetes, but this is metabolized extremely rapidly by the ubiquitous enzyme, dipeptidyl peptidase IV (DPP IV), forming a metabolite, which acts as an antagonist at the GLP-1 receptor. (omitted)

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