Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.298.1-298.1
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- 2003
Protective Effects of Acanthoic acid on Tertiary-Butyl Hydroperoxide or Carbon tetrachloride-Induced Liver Injury
- Park, Eun-Jeon (Department of Pharmacy, Wonkwang University) ;
- Nan, Ji-Xing (College of Pharmacy, Chungnam National University) ;
- Zhao, Yu-Zhe (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
- Lee, Sung-Hee (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
- Kim, Young-Ho (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
- Nam, Jeong-Bum (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
- Lee, Jung-Joon (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnolog) ;
- Sohn, Dong-Hwan (Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology)
- Published : 2003.04.01
Abstract
The aim of this study was to investigate the protective effect of acanthoic acid on liver injury induced by either tertiary-butyl hydroperoxide (tBH) or carbon tetrachloride in vitro and in vivo. Acanthoic acid, (-)-pimara-9(11),15-diene-19-oic acid, is a diterpene isolated from the root bark of Acanthopanax koreanum. In in vitro study, the cellular leakage of lactate dehydrogenase (LDH) with 1.5 mM tBH for 1 j, were significantly inhibited by treatment with acanthoic acid(25 and 5mg/mL). (omitted)
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