Multivesicular DepoFoam particles for oral delivery of recombinant human epidermal growth factor

  • Li, Hong (College of Pharmacy, Chungbuk National University) ;
  • An, Jun-Hee (College of Pharmacy, Chungbuk National University) ;
  • Park, Jeong-Sook (College of Pharmacy, Chungbuk National University) ;
  • Han, Kun (College of Pharmacy, Chungbuk National University)
  • Published : 2003.04.01

Abstract

Multivesicular DepoFoam technology is best suited for the encapsulation and sustained release of water-soluble drugs. The purpose of the present study was to prepare multivesicular DepoFoam particles and investigated possibility of oral delivery of a peptide, human epidermal growth factor (rhEGF). The multivesicular DepoFoam particles containing rhEGF was prepared by a two step water-in-oil-in-water double emulsification process. (omitted)

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