Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.248.3-249
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- 2003
Synthesis and cyclooxygenase-2 inhibitory activity of tetrahydroaminoacridine and their analogues
- Shin, H.S. (College of Pharmacy, Duksung Women′s University) ;
- Kang, J.Y. (College of Pharmacy, Duksung Women′s University) ;
- Park, M.S. (College of Pharmacy, Duksung Women′s University) ;
- Kwon, S.K. (College of Pharmacy, Duksung Women′s University)
- Published : 2003.04.01
Abstract
A series of tetrahydroaminoacridine and their analogues were synthesized. Tetrahydroaminoacridine(tacrine) is an anticholinesterase agent used in the treatment of Alzheimer's disease. Introduction of piperidine group at the para position enhanced anti-inflamatory activity for Alzheimer's disease. We investigated their ability to inhibit cyclooxygenase-1 and 2 isoforms. (omitted)
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