Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Ircinin-1 from the Sponge Sarcotragus sp. Induces of Apoptosis in SK-MEL-2 Human Skin Cancer Cells

  • Choi, Hye-Joung (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center) ;
  • Yee, Su-Bog (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Cente) ;
  • Chung, Sang-Woon (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Cente) ;
  • Park, Sang-Eun (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Cente) ;
  • Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University and Research Center of Oriental Medicin) ;
  • Jung, Jee-Hyung (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Cente) ;
  • Kim, Nam-Deuk (Department of Pharmacy, Pusan National University, and Pusan Cancer Research Center)
  • Published : 2003.04.01
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Abstract

The marine sponge of the genus Petrosia sp. is known to contain unique metabolites such as furanoterpenoids. These furanoterpenoids have been reported to possess various bioactivities. We have shown previously that ircinin-1 induced cell cycle arrest and apoptosis in SK-MEL-2 human skin cancer cells dose- and time-dependently. In this study. we demonstrated that ircinin-1-induced apoptosis is a accompanied by cleavage of poly(ADP-ribose) polymerase protein and PLC-${\gamma}$1 degradation and release of cytochrome c from mitochondria to cytosol. (omitted)

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