Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.209.1-209.1
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- 2003
Modulation of Cytochrome P450 1B1 Expression by A Stilbene Analog and its Effect on the Sensitivity to Anticancer Agents in Human Cancer Cells.
- Lee, Sang-Kwang (Chungang University) ;
- Park, Sung-Sik (Chungang University) ;
- Kim, Mie-Young (Chungang University) ;
- Chun, Young-Jin (Chungang University)
- Published : 2003.04.01
Abstract
We have previously shown that 2, 3', 4, 5' -tetramethoxystilbene(TMS) from synthetic trans-stilbene analogues, is one of the most potently selective inhibitor of recombinant human cytochrome P450 1B1 in vitro. In the present studies. the effects of TMS on the expression of cytochrome P450 1B1 were investigated in human cancer cell lines such as MCF-7 and HL -60. TCDD-stimulated P450 1B1 protein and mRNA expression was significantly suppressed by TMS in a dose-dependent manner. (omitted)
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