Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.209.2-210
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- 2003
Anti-inflammatory effect of indole compound, IND-6 in LPS-stimulated RAW 264.7 murine macrophage cell line
- Park, Young-Mi (College of Pharmacy, Kyunghee University) ;
- Kim, In-Tae (College of Pharmacy, Kyunghee University) ;
- Jung, Jin-Hyun (College of Pharmacy, Kyunghee University) ;
- Mun, Han-Seo (College of Pharmacy, Kyunghee University) ;
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Lee, Kyung-Tae
(College of Pharmacy, Kyunghee University)
- Published : 2003.04.01
Abstract
Nitric oxide (NO) and prostagladins(PGs) produced by inducible nitric oxide synthase(iNOS) and cyclooxygenase(COX-2) are known as inflammatory mediator. Modulation of these enzymes, induced by many stimuli(LPS, IFN-gamma, TNF-alpha, phorbol ester, etc), is a potent strategy as treatment of inflammatory diseases. Treatment of murine macrophage RAW 264.7 cell line with indole compound(IND-6) markedly reduced lipopolysacchride(LPS) stimulated NO production in a concentration-related manner. (omitted)
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