Interleukin-12 as a Therapeutic Target of Th1-mediated Autoimmune Diseases

  • Kim, Tae-Sung (College of Pharmacy, Chonnam National University)
  • Published : 2003.04.01

Abstract

In the past it was thought that autoimmunity is mediated by antibodies and immune complexes. It has now become clear that many diseases, especially tissue specific, are T cell mediated or at least T cell dependent. The pathogenesis of cell-mediated autoimmune diseases, such as multiple sclerosis, uveitis, diabetes, arthritis, and others, is thought to be in a large measure driven by interferon-gamma-producing antigen-specific T cells polarized toward the Th1 phenotype. (omitted)

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