The Two Faces of IL-18 in Tumor Immunology

  • Cho, Dae-Ho (Department of Life Science, Sookmyung Women′s University)
  • Published : 2003.04.01

Abstract

IL-18 has been found to have multiple effects upon various cells involved in tumor immunology. Here, we discuss opposite effects of IL-18 in tumor immunology. IL-18 has been shown that it has significant anti-tumor effects, which are mediated by T cells and NK cells, in a manner similar to IL-12. First, we investigated the evaluation of the effects of the systemic administration of IL-18 in combination with B7-1 (CD80) against murine B16 melanoma in vivo. (omitted)

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