Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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New Analytical Method of Cyclosporine A in Human Serum by High -performance Liquid Chromatography/Diode Array Detector and Its Application to Pharmacokinetics of Cyclosporine A in Human Volunteers

  • Kim, Eun-Young (Loxicology Lab., Korea Institute of Science and Technology) ;
  • Chung, Yeon-Bok (College of Pharmacy. Chungbuk National University) ;
  • Kwon, Oh-Seung (Loxicology Lab., Korea Institute of Science and Technology)
  • Published : 2002.10.01
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Abstract

A simple. specific and sensitive method for the determination of cyclosporine A (CsA) in human serum has been developed by a high performance liquid chromatography/diode array detector (DAD) and applied to pharmacokinetic study of CsA. This method involves the use of solid phase extraction procedure following rapid protein precipitation with zinc sulphate from 1 $m\ell$ of human serum, using a disposable $C_{18}$ extraction cartridge. (omitted)

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