Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.422.2-423
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- 2002
Kinetic Analysis of the Hepatic Uptake and Biliary Excretion of IH-901. a Potential Anticancer Agents. in Rats
- Lee, Pung-Sok (College of Pharmacy. Chungbuk National University) ;
- Sung, Jong-Hwan (Natural Products Research Lab., Ilhwa Co., Ltd) ;
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Chung, Youn-Bok
(College of Pharmacy. Chungbuk National University)
- Published : 2002.10.01
Abstract
The purpose of the present study was to investigate the hepatic uptake and biliary excretion of IH-901. a potential anticancer agents. in rats. IH-901 was mainly distributed into the liver after its iv administration at the dose of 10-30 mg/kg. The liver concentration of IH-901 at 7 min after its Iv administration was comparable with its initial concentration of the plasma. Moreover. recovery ratio of IH-901 in the bile for 6 hr was more than 40% after its iv administration. (omitted)
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