Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.344.1-344.1
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- 2002
Synthesis of Novel 3-Aminohydantoinyl-1.2-benzothiazine Derivatives for the COX-2 inhibitors
- Park, Myung-Sook (College of Pharmacy. Duksung Women′s University) ;
- Lee, Myung-Sook (College of Pharmacy. Duksung Women′s University) ;
- Shin, Hae-Soon (College of Pharmacy. Duksung Women′s University) ;
- Kwon, Soon-Kyoung (College of Pharmacy. Duksung Women′s University)
- Published : 2002.10.01
Abstract
We report the synthesis of several new 3-aminohydantoinyl-1.2-benzothiazine derivatives and propose an another mechanism of the cyclization to the hydantoins for the development candidates of COX-2 inhibitors. 3-Aminohydantoins 3a-d were prepared through cyclization of the condensation products that were formed by heating amino acids and tert-bytyl carbazate in quinoline according to the method of Lalezari. (omitted)
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