Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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5-Arylidene-2(5H)-furanone Derivatives: Synthesis and Structure-Activity Relationship toward Cytotoxicity

  • Bang, Seong-Cheol (College of Pharmacy, Chungnam National University) ;
  • Kim, Yong (College of Pharmacy, Chungnam National University) ;
  • Yun, Mi-Young (Lab of Pathology, College of Oriental Medicine Daejeon Universiy) ;
  • Kim, Dong-Hee (Lab of Pathology, College of Oriental Medicine Daejeon Universiy) ;
  • Ahn, Byung-Zun (College of Pharmacy, Chungnam National University)
  • Published : 2002.10.01
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Abstract

Ranunculin (RAN). isolated from Ranunculaceae. exhibited significant cytotoxic activity against KB and Bel-7402 cells with ED$_{50}$ values of 0.21 and 0.35).${\mu}4M respectively. Under physiological condition. the ranunculin was deglycosylated to be protoanemonin. an active form containing ${\alpha}{\beta}$-unsaturated ketone moiety. which successively dimerized to be anemonin inactive form. (omitted)

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