Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.337.3-338
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- 2002
Decusinol angelate inhibits UVB-induced MMP-l induction via Mitogen-activated Protein Kinase Pathway in human skin fibroblasts
- Wang, Hye-Sung (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
- Kang, Sun-Myung (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
- Cho, Hong-Yon (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
- Ho, Jin-Nyung (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University) ;
- Kim, Ik-Hwan (Lab. of Cell Culture Engineering, Graduate School of Biotechnology. Korea University)
- Published : 2002.10.01
Abstract
UV-B irradiation increases the synthesis of matrixmetalloproteinase-1 (MMP-1) that degrades skin collagen in human skin. In this work, we investigated the photoprotective effect of decursinol angelate (DEA) extracted Irom Angelica gigas on human skin libroblasts. DEA inhibited UVB-induced MMP-1 induction, which was conlirmed by western blot and ELISA. We examined upstream signal transduction pathway and the action mechanism of DEA on UVB induction of MMp in human skin fibroblasts. (omitted)
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