Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Anti-angiogenic activity of conjugated linoleic acid on the basic fibroblast growth factor-induced angiogenesis

  • Moon, Eun-Joung (Department of Moleular Biology, Pusan National University) ;
  • Lee, You-Mie (Research Institute of Pharmaceutical College of Pharmacy. Seoul National University) ;
  • Kim, Kyu-Won (Research Institute of Pharmaceutical College of Pharmacy. Seoul National University)
  • Published : 2002.10.01
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Abstract

Conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. Cancer cells produce various angiogenic factors which stimulate host vascular endothelial cell mitogenesis and chemotaxis for their growth and metastasis. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor that is expressed in many tumors. In this study. we found that CLA decreased bFGF-induced endothelial cell proliferation and DNA synthesis in a dose-dependent manner. However, CLA did not inhibit endothelial cell migration. Furthermore CLA showed a potent inhibitory effect on embryonic vasculogenesis and bF GF-induced angiogenesis in vivo. Collectively. these results suggest that CLA selectively inhibis the active proliferating endothelial edll induced by bFGF. which may explain its anti-carcinogenix properties in vivo.

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