Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.335.1-335.1
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- 2002
The ermKleader peptide alterations leading to differential efficiency of induction by erythromycin
- Kim, Jeong-A (Seoul National University) ;
- Min, Yu-Hong (Seoul National University) ;
- Yun, Hee-Jeong (Seoul National University) ;
- Lim, Jung-A (Seoul National University) ;
- Lee, Sang-Won (Seoul National University) ;
- Kim, ung-Hoon (Seoul National University) ;
- Park, Eung-Chil (Seoul National University)
- Published : 2002.10.01
Abstract
The ermK gene from Bacillus lichenformis encodes an inducible rANA methylase that confers resistance to the macrolide-lincosamide-streptograminB antibiotics. The ermKmANA leader sequence has a total length of 357 nucleotides and encodes a 14-amino acid leader peptide together with its ribosome binding site. The secondary structure of erm leader RNA and a leader peptide have been reported as the elements that control expression. (omitted)
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