Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.334.3-334.3
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- 2002
The properties of ginseng saponins metabolizing intestinal bacteria
- Choo, Min-Kyung (College of Pharmacy KyungHee University) ;
- Lee, Mi-Ji (Il Hwa Central Research Institute) ;
- Sung, Jong-Hwan (Il Hwa Central Research Institute) ;
- Park, Sung-Hwan (Il Hwa Central Research Institute) ;
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Kim, Dong-Hyun
(Il Hwa Central Research Institute)
- Published : 2002.10.01
Abstract
Ginseng(the root of Panax ginseng C.A. Meyer, Araliaceae) has been used for thousands of years as a traditional medicine in Asian countries. The main components of Ginseng are ginsenoside Rb1, Rb2 and Rc. These compounds are transformed by intestinal microflora. The main metabolite of ginsenosides was compoud K (IH-901). The transformed compound K shows an antimetastic or anticarcinogenic effect by blocking tumor invasion or preventing chromosomal aberration and tumorigenesis. Therefore. we isolated and characterzed ginseng saponin-metabolizing bacteria from human intestinal microffora. Among 200 tested intestinal bacteria. we found 78 bacteris to transform glnseng senseng saponins to compound K. These bacteria were seperated into three group: the first group highy produced ginsenside Rd (29) the second grop produced potently ginsenoside F2 (21) and the third produced compound K(28)
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