Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.335.2-335.2
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- 2002
Pathogenic and immunological properties of alcohol dehydrogenase in Streptococcus pneumoniae
- Park, Sin-Hee (College of Pharmacy Sungkyunkwan University) ;
- Kwon , Hyog-Young (College of Pharmacy Sungkyunkwan University) ;
- Park, Moo-Hyun (College of Pharmacy Sungkyunkwan University) ;
- Lee, Kwang-Jun (Korea National Institute of Healt) ;
- Kim, Ki-Sang (Korea National Institute of Healt) ;
- Pyo, Suhk-Neung (Korea National Institute of Healt) ;
- Rhee , Dong-Kwon (College of Pharmacy Sungkyunkwan University)
- Published : 2002.10.01
Abstract
Despite the use of antibiotics and vaccines, Streptococcus pneumoniae remains a serious cause of morbidity and morality in human. In this study, pathogenic and immunological natures of alcohol dehydrogenase (ADH) in S. pneumoniae were elucidated. In vitro cytotoxicity test determined by lactate dedydrogenase release from A549 cells revealed that adh mutation significantly reduced cytotoxicity although in vivo intraperitoneal challenge of the adh mutant to BALB/C mouse exhibited marginal increase of survival time than the wild type. (omitted)
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