Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Immunomodulatory activity of a polysaccharide isolated from cell culture of Acantopanax senticosus

  • Ahn, Hyo-Jung (Biopotency Evaluation Laboratory) ;
  • Han, Sang-Bae (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Yoon, Yeo-Dae (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Lee, Haeng-Soon (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Moon, Jae-Sun (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Lee, Chang-Woo (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Lee, Ki-Hoon (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Park, Song-Kyu (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Kim, Hyung-Chin (Korea Research Institute of Bioscience Biotechnology(KRIBB)) ;
  • Kim, Hwan-Mook (Korea Research Institute of Bioscience Biotechnology(KRIBB))
  • Published : 2002.10.01
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Abstract

Many polysaccharides isolated from plants are considered to be biological response modifiers and have been shown to enhance various immune responses in vivo and in vitro. Here we demonstrate that a polysaccharide isolated from cell culture of Acanthopanax senticosus (AS) has a unique mode of immunostimulation with regard to its cell-type specificity. AS was found to markedly increase polyclonal IgM antibody production and the proliferation of B cells. and to activate iNOS transcription and NO production in macrophages. (omitted)

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