Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.258.2-258.2
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- 2002
Mechanism of immunostimulating action of polysaccharide isolated from Platycodon grandiflorum in RAW 264.7 macrophages
- Yoon, Yeo-Dae (Kor Res Inst Biosci Biotech (KRIBB)) ;
- Han, Sang-Bae (Kor Res Inst Biosci Biotech (KRIBB)) ;
- Hong, Dong-Ho (Kor Res Inst Biosci Biotech (KRIBB)) ;
- Kang, Jong-Seong (Coliege of Pharmacy. Chungnam Natl. Univ.) ;
- Lee, Hyun-Sun (Kor Res Inst Biosci Biotech (KRIBB)) ;
- Kim, Hwan-Mook (Kor Res Inst Biosci Biotech (KRIBB))
- Published : 2002.10.01
Abstract
In our previous study. we reported that PG. a polysaccharide isolated from Plyatycodon grandiflorum, activated macrophages and B cells. but not T cells. Here. we investigated in more detail the mechanism of action of PG in macrophage activation. Since PG cannot penetrate cells due to the large molecular mass, it should bind to membrane receptors of macrophages. We showed that some antibodies to cell surface molecules (CD14, CD11b. TLR2, and TLR4) inhibited RAW264.7 macrophage activation, suggesting the possible binding sites of PG. (omitted)
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