Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.248.3-249
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- 2002
Inhibitory effects of new quinone compounds on eNOS activity in rat aorta and nNOS activity in rat brain
- Yoo, So-Yeon (Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University) ;
- Seo, Ji-Hui (Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University) ;
- Ryu, Chung-Kyu (Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University) ;
- Kim, Hwa-Jung (Research Institute of Pharmaceutical Sciences, College of Pharmacy Ewha Womans University)
- Published : 2002.10.01
Abstract
Nitric oxide (NO) has been shown to play an important role in the regulation of vascular tone. platelet function. neurotransmission. and immune function. NO is synthesized from the L-arginine by NO synthase (NOS). Three distinct isoforms of NOS have been identified: calcium/calmodulin-dependent endothelial (eNOS) and neuronal (nNOS) isoforms which are constitutive and produce small quantities of NO, and an inducible isoform (iNOS) which is markedly induced in response to lipopolysaccharide (LPS) or inflammatory cytokines. (omitted)
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