Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
- /
- Pages.249.1-249.1
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- 2002
Attenuation of monocrotaline-induced pulmonary hypertension with DA-8159, a potent PDE 5 inhibitor
- Ahn, Gook-Jun (Dong-A Pharmaceutical Research Institute) ;
- Kang, Kyung-Koo (Dong-A Pharmaceutical Research Institute) ;
- Sohn, Yong-Sung (Dong-A Pharmaceutical Research Institute) ;
- Choi, Seu-Min (Dong-A Pharmaceutical Research Institute) ;
- Kim, Ju-Mi (Dong-A Pharmaceutical Research Institute) ;
- Kim, Dong-Hwan (Dong-A Pharmaceutical Research Institute) ;
-
Ahn, Byoung-Ok
(Dong-A Pharmaceutical Research Institute)
;
- Kim, Won-Bae (Dong-A Pharmaceutical Research Institute)
- Published : 2002.10.01
Abstract
This study was carried out to demonstrate the effects of oral administration of DA-8159. a selective phosphodiesterase 5 inhibitor. on development of pulmonary hypertension induced by monocrotaline (MCT). MCT-treated rats(60mg/kg) were divided into three groups and orally administered vehicle, 1 mg/kg or 5 mg/kgg of DA-8159 twice a day for 3 weeks. Increased right ventricular weights, medial wall thickening in pulmonary arteries. myocardial fibrosis, decrease of plasma cyclic guanosine monophosphate (cGMP) level and body weight gains were shown in MCT group. (omitted)
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