Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.241.2-241.2
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- 2002
Determination of Optical Purity of a-Arylmethylpropionic acds by Normal Phase Liquid Chromatography
- Min-Chungsik (KFDA) ;
- Jae, Jang-Seung (KFDA) ;
- Lee, Song-Deuk (KFDA) ;
- Park, Seung-Hee (KFDA) ;
- Yun, Jang-Jung (KFDA) ;
- Yun, Jung-Hae (KFDA) ;
- Lee, Keang-Hee (KFDA) ;
- Hae, Jo-Seung (KFDA) ;
- In, Jo-Keang (KFDA)
- Published : 2002.10.01
Abstract
A various 2-arylmethylpropionic acds(profen) have been widely used as non-steroidal anti-inllammatory drugs for the relief of acute and chronic rheumatoid arthritis and osteoarthritis. as well as for other connective tissue disorders and pains. Example is fenoprofen. ibuprofen, ketoprolen, and naproxen. All are chiral and, except for naproxen. are marketed in racemic form. Enantioseparations of profens have been of considerable interest because their anti-inflammatory and analgesic effects have been attributed almost exclusively to their (S)-enantiomer. (omitted)
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